Buy Cymbalta Online

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Cymbalta (Duloxetine)

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Product form of cymbalta or duloxetine- cymbalta generic.
Pills:
cymbalta 40 mg (Normal Dosage)
cymbalta 30 mg (Low Dosage)
cymbalta 20 mg (Extra Low Dosage).

Pharmacological action.
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Cymbalta is a new, long-awaited treatment for depression and painful form of diabetic neuropathy. Cymbalta has a central mechanism for the suppression of pain, which, in the first place, manifested by increased sensitivity to pain with neuropathic pain syndrome etiology.
Inhibits the reuptake of serotonin and noadrenalina, resulting in increased serotonergic and noradrenergic Neurotransmission in the CNS. Weakly inhibits dopamine grip, without having a significant affinity for histaminergic, dopaminergic, cholinergic and adrenergic receptors.

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Pharmacokinetics.
After oral administration, duloxetine- cymbalta generic is well absorbed from the gastrointestinal tract, absorption begins after 2 h, Cmax achieved after 6 hours. Food reduces the extent of absorption (approximately 11%) did not affect the value, but increases the time to Cmax to 10 hours.
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The half-life is 12 h. The average clearance of duloxetine is 101 L / h. Excreted in the urine as metabolites.
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In conducting research established some differences between the pharmacokinetic processes in men and women (average clearance of duloxetine lower in women), but it need not dose adjustment.

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Indications for use.
• depression;
• painful form of diabetic neuropathy.

It's necessary to know how to use duloxetine- cymbalta generic .
Dosage.
The recommended starting dose is 60 mg 1 time / day (cymbalta 40 mg + cymbalta 20 mg or 2 pills cymbalta 30 mg) . If necessary, you can increase the daily dose from 60 mg to a maximum dose of 120 mg / day (divided into 2 doses). A systematic evaluation of the safety of the drug in doses above 120 mg was not done.
In patients with severe renal impairment, the initial dose is 30 mg 1 time / day.
There is no clinical experience with the drug for patients under 18 years.
The capsules should be swallowed whole without chewing or crushing. You can not add medication to food or mix it with fluids, because this may damage the enteric shell pellets. The drug can be taken with or without of food .

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Side Effects.
Central nervous system: often - dizziness, sleep disturbances, headache .
From the digestive system: common - dry mouth, nausea, and sometimes - diarrhea, loss of appetite.
Other: sometimes - weight loss, increased sweating.

If you need to buy cymbalta or duloxetine- cymbalta generic, you have to know contraindications.
Contraindications.
Hypersensitivity, asthma-closure glaucoma, lactation, age till 18 years.
Use of the drug during pregnancy is possible only in cases where the intended benefits to the mother outweighs the potential risk to the fetus, because clinical experience with duloxetine in pregnancy is not enough.

Overdose.
Several cases of overdose with one-stage intake to 1.4 grams of the drug, not leading to death.
Symptoms: tremor, loss of appetite. Treatment: recommend control of the cardiovascular system and other vital signs, if necessary, symptomatic therapy. No specific antidote.

Storage.
The drug should be stored out of reach of children at a temperature of 15 ° to 30 ° C. Shelf life - 2 years.

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